Leong F J, Meredith D J
University of Oxford, Nuffield Department of Pathology & Bacteriology, John Radcliffe Hospital, England.
Pathol Res Pract. 1998;194(9):661-5; discussion 666-7.
Verruciform xanthoma is a benign lesion of the oral cavity and skin, which is characterized by aggregates of bland foamy histiocytes (xanthoma cells) within the connective tissue and underlying acanthotic, parakeratotic hyperplastic epithelium with elongated rete ridges. We describe a rare case of vulval verruciform xanthoma in an 84-year-old, which was clinically mistaken for malignant tumor. Immunohistochemistry confirmed the histiocytic nature of the foamy cells and electron microscopy showed the cytoplasmic vacuoles to contain lipid. A finding as yet undocumented in the literature was the presence of foamy histiocytes within the draining lymph nodes. This case highlights clinical mimicry of a malignant tumor by anogenital verruciform xanthoma.
疣状黄色瘤是口腔和皮肤的一种良性病变，其特征是结缔组织内有大量形态温和的泡沫状组织细胞（黄色瘤细胞），其下方为棘层肥厚、不全角化的增生上皮，伴有延长的 rete 嵴。我们描述了一例 84 岁女性罕见的外阴疣状黄色瘤病例，该病例临床上被误诊为恶性肿瘤。免疫组化证实了泡沫细胞的组织细胞性质，电子显微镜显示细胞质空泡内含有脂质。文献中尚未记载的一个发现是引流淋巴结内存在泡沫状组织细胞。该病例突出了肛门生殖器疣状黄色瘤对恶性肿瘤的临床模仿。
