Morrison P J, Macphail S, Williams D, McCusker G, McKeever P, Wright C, Nevin N C
Department of Medical Genetics, Belfast City Hospital Trust, U.K.
Prenat Diagn. 1998 Sep;18(9):963-7.
Congenital atresia of the larynx is a rare abnormality. We describe three cases where prenatal diagnosis during the second trimester showed massive abdominal fetal ascites and at post-mortem, laryngeal atresia was identified in two cases, and severe laryngeal stenosis in the third. All were associated with pulmonary hyperplasia. No additional abnormalities were found in other systems. Overdistended lung tissue and ascites are resultant from aberrant laryngeal growth; laryngeal anomalies are a cause of isolated fetal ascites. The association of ascites and voluminous lungs should arouse suspicion of laryngeal atresia and should be an indication for careful pathological study of the fetal larynx.
先天性喉闭锁是一种罕见的异常情况。我们描述了三例病例，其中孕中期的产前诊断显示胎儿腹部大量腹水，尸检时，两例发现喉闭锁，第三例发现严重喉狭窄。所有病例均伴有肺增生。其他系统未发现额外异常。肺组织过度扩张和腹水是喉异常生长的结果；喉异常是孤立性胎儿腹水的一个原因。腹水与肺肿大的关联应引起对喉闭锁的怀疑，并且应成为对胎儿喉部进行仔细病理研究的指征。
