Saul J P
Children's Heart Center, Medical University of South Carolina, Charleston 29425, USA.
Fundam Clin Pharmacol. 1998;12 Suppl 1:17s-22s. doi: 10.1111/j.1472-8206.1998.tb01027.x.
The transfer function between broad-band respiratory activity and the heart rate (HR) response can be used to elucidate the frequency dependent phase and magnitude characteristics of the respiratory sinus arrhythmia (RSA). To understand the complex links between respiratory activity and arterial blood pressure (ABP), the transfer functions between instantaneous lung volume (ILV), parameters of arterial pressure, and central venous pressure (CVP) were determined in healthy human volunteers during 6-minute periods in which the respiratory rate was voluntarily controlled in a predetermined but erratic fashion, or CVP was perturbed with a similar pattern. Pharmacologic autonomic blockade was used to dissect the direct mechanical links between respiration and ABP from the effects of RSA on ABP. The results suggest that with HR fluctuations eliminated, respiration affects ABP in proportion to the rate of change of ILV; however, when neural control of HR remains intact, the RSA plays an important role in the genesis of ABP fluctuations.
宽带呼吸活动与心率（HR）反应之间的传递函数可用于阐明呼吸性窦性心律不齐（RSA）的频率依赖性相位和幅度特征。为了理解呼吸活动与动脉血压（ABP）之间的复杂联系，在健康人类志愿者中，在6分钟内确定了瞬时肺容积（ILV）、动脉压参数和中心静脉压（CVP）之间的传递函数，在此期间，呼吸频率以预定但不稳定的方式进行自主控制，或者CVP以类似模式受到扰动。使用药理学自主神经阻滞来区分呼吸与ABP之间的直接机械联系以及RSA对ABP的影响。结果表明，消除心率波动后，呼吸对ABP的影响与ILV的变化率成比例；然而，当心率的神经控制保持完整时，RSA在ABP波动的发生中起重要作用。
