Martin-Paredero V, Vadillo J, Diaz J, Espinosa A, Berga C, Segura J, Sanchez J, Barbod A, Villaverde C, Richard C M
University Hospital Joan XXIII, Tarragona, Spain.
Cardiovasc Surg. 1998 Oct;6(5):457-62. doi: 10.1016/s0967-2109(98)00001-5.
High plasma fibrinogen appears to be an important risk factor for the development of atherosclerosis. The aim of our study was to measure fibrinogen and fibrin degradation products (D-dimer), interleukin-6 tissue plasminogen activator, plasminogen activator inhibitor-1 and urokinase-type plasminogen activator in the plasma and arterial walls of 45 patients who had arterial surgery between April 1993 and November 1995. The arterial specimens were also examined by immunohistochemists for these same factors. The serum fibrinogen and fibrin degradation products were high in all patients, and fibrinolysis was depressed. Few leukocytes were seen in the arterial walls, which had poor fibrinolytic activity. Plasminogen-activator inhibitor activity in the wall was also reduced in the affected arterial walls. The abdominal aorta appeared to have the highest levels of fibrinogen and this may be related to its ability to form aneurysms. Fibrinogen may play an important role in the progression of atherosclerotic disease.
高血浆纤维蛋白原似乎是动脉粥样硬化发展的一个重要危险因素。我们研究的目的是测定1993年4月至1995年11月期间接受动脉手术的45例患者血浆和动脉壁中的纤维蛋白原、纤维蛋白降解产物（D-二聚体）、白细胞介素-6、组织型纤溶酶原激活剂、纤溶酶原激活剂抑制剂-1和尿激酶型纤溶酶原激活剂。还通过免疫组织化学方法对动脉标本进行了这些相同因子的检测。所有患者的血清纤维蛋白原和纤维蛋白降解产物均升高，纤溶功能受到抑制。在纤维蛋白溶解活性较差的动脉壁中，几乎看不到白细胞。病变动脉壁中的纤溶酶原激活剂抑制剂活性也降低。腹主动脉似乎具有最高水平的纤维蛋白原，这可能与其形成动脉瘤的能力有关。纤维蛋白原可能在动脉粥样硬化疾病的进展中起重要作用。
