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1
Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase.早幼粒细胞白血病蛋白与3-磷酸甘油醛脱氢酶之间RNA依赖性核相互作用的证明。
Biochem J. 1998 Nov 1;335 ( Pt 3)(Pt 3):691-6. doi: 10.1042/bj3350691.
2
[Promyelocytic leukaemia protein and defect in transforming growth factor-beta signal pathway in acute promyelocytic leukaemia].[早幼粒细胞白血病蛋白与急性早幼粒细胞白血病中转化生长因子-β信号通路缺陷]
Cas Lek Cesk. 2005;144(2):90-4.
3
The promyelocytic leukemia (PML) protein suppresses cyclin D1 protein production by altering the nuclear cytoplasmic distribution of cyclin D1 mRNA.早幼粒细胞白血病（PML）蛋白通过改变细胞周期蛋白D1信使核糖核酸的核质分布来抑制细胞周期蛋白D1蛋白的产生。
Oncogene. 2000 Mar 23;19(13):1623-34. doi: 10.1038/sj.onc.1203473.
4
Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.调亡素通过小泛素样修饰物缀合作用进行修饰，并靶向早幼粒细胞白血病蛋白核体。
Oncogene. 2007 Mar 8;26(11):1557-66. doi: 10.1038/sj.onc.1209923. Epub 2006 Aug 21.
5
Cell cycle-dependent association of PML bodies with sites of active transcription in nuclei of mammalian cells.哺乳动物细胞核中PML小体与活跃转录位点的细胞周期依赖性关联。
J Struct Biol. 2002 Oct-Dec;140(1-3):167-79. doi: 10.1016/s1047-8477(02)00571-3.
6
The function of PML in p53-dependent apoptosis.PML在p53依赖性细胞凋亡中的作用。
Nat Cell Biol. 2000 Oct;2(10):730-6. doi: 10.1038/35036365.
7
THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies.THAP1是一种核促凋亡因子，它将前列腺凋亡反应蛋白4（Par-4）与早幼粒细胞白血病（PML）核体联系起来。
Oncogene. 2003 Apr 24;22(16):2432-42. doi: 10.1038/sj.onc.1206271.
8
Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus.PML 小体在哺乳动物细胞核内的代谢能量依赖型运动。
Nat Cell Biol. 2002 Feb;4(2):106-10. doi: 10.1038/ncb740.
9
Functional proteomic analysis of promyelocytic leukaemia nuclear bodies in irradiation-induced MCF-7 cells.辐射诱导 MCF-7 细胞中早幼粒细胞白血病核小体的功能蛋白质组学分析。
J Biochem. 2010 Dec;148(6):659-67. doi: 10.1093/jb/mvq105. Epub 2010 Sep 7.
10
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.AXIN 是早幼粒细胞白血病蛋白在 p53 激活中的必需共激活因子。
Oncogene. 2011 Mar 10;30(10):1194-204. doi: 10.1038/onc.2010.499. Epub 2010 Nov 8.

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1
The diverse functions of GAPDH: views from different subcellular compartments.GAPDH 的多种功能：来自不同亚细胞隔室的观点。
Cell Signal. 2011 Feb;23(2):317-23. doi: 10.1016/j.cellsig.2010.08.003. Epub 2010 Aug 19.
2
Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration.氧化修饰的甘油醛-3-磷酸脱氢酶（GAPDH）与阿尔茨海默病：神经退行性变的多条途径。
J Alzheimers Dis. 2010;20(2):369-93. doi: 10.3233/JAD-2010-1375.
3
Finding one's way in proteomics: a protein species nomenclature.蛋白质组学中的探索之路：一种蛋白质种类命名法。
Chem Cent J. 2009 Sep 9;3:11. doi: 10.1186/1752-153X-3-11.
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Biological targets for isatin and its analogues: Implications for therapy.异吲哚酮及其类似物的生物学靶点：对治疗的意义。
Biologics. 2007 Jun;1(2):151-62.
5
Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication.卡波西肉瘤相关疱疹病毒无内含子mRNA的核输出及病毒复制需要完整的hTREX复合物的募集。
PLoS Pathog. 2008 Oct;4(10):e1000194. doi: 10.1371/journal.ppat.1000194. Epub 2008 Oct 31.
6
Regulation of oncogenic transcription factor hTAF(II)68-TEC activity by human glyceraldehyde-3-phosphate dehydrogenase (GAPDH).人甘油醛-3-磷酸脱氢酶（GAPDH）对致癌转录因子hTAF(II)68-TEC活性的调控
Biochem J. 2007 Jun 1;404(2):197-206. doi: 10.1042/BJ20061297.
7
Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.真核生物翻译起始因子4E的活性在多个水平上受到HOXA9的调控。
Mol Cell Biol. 2005 Feb;25(3):1100-12. doi: 10.1128/MCB.25.3.1100-1112.2005.
8
Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis.异常的真核生物翻译起始因子4E依赖的mRNA转运阻碍造血分化并促进白血病发生。
Mol Cell Biol. 2003 Dec;23(24):8992-9002. doi: 10.1128/MCB.23.24.8992-9002.2003.
9
The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.富含脯氨酸的同源结构域蛋白PRH是一种对eIF4E依赖性细胞周期蛋白D1信使核糖核酸转运和生长具有组织特异性的抑制剂。
EMBO J. 2003 Feb 3;22(3):689-703. doi: 10.1093/emboj/cdg069.
10
Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies.思考早幼粒细胞白血病蛋白（PML）之谜：PML核体的可能功能
Mol Cell Biol. 2002 Aug;22(15):5259-69. doi: 10.1128/MCB.22.15.5259-5269.2002.

本文引用的文献

1
Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.Ret指蛋白是早幼粒细胞白血病（PML）核体的正常组成部分，并直接与PML相互作用。
J Cell Sci. 1998 May;111 ( Pt 10):1319-29. doi: 10.1242/jcs.111.10.1319.
2
Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.新生RNA与含PML核体中CREB结合蛋白的定位
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4991-6. doi: 10.1073/pnas.95.9.4991.
3
Two RING finger proteins, the oncoprotein PML and the arenavirus Z protein, colocalize with the nuclear fraction of the ribosomal P proteins.两种环状结构域蛋白，即癌蛋白早幼粒细胞白血病蛋白（PML）和沙粒病毒Z蛋白，与核糖体P蛋白的核部分共定位。
J Virol. 1998 May;72(5):3819-26. doi: 10.1128/JVI.72.5.3819-3826.1998.
4
Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis.在经历凋亡的培养小脑神经元中过表达的甘油醛-3-磷酸脱氢酶的核定位。
Mol Pharmacol. 1998 Apr;53(4):701-7. doi: 10.1124/mol.53.4.701.
5
Role of PML in cell growth and the retinoic acid pathway.早幼粒细胞白血病蛋白（PML）在细胞生长及视黄酸途径中的作用。
Science. 1998 Mar 6;279(5356):1547-51. doi: 10.1126/science.279.5356.1547.
6
The promyelocytic leukemia protein PML has a pro-apoptotic activity mediated through its RING domain.早幼粒细胞白血病蛋白PML具有通过其RING结构域介导的促凋亡活性。
FEBS Lett. 1997 Nov 24;418(1-2):30-4. doi: 10.1016/s0014-5793(97)01344-6.
7
Cell death induction by the acute promyelocytic leukemia-specific PML/RARalpha fusion protein.急性早幼粒细胞白血病特异性PML/RARα融合蛋白诱导细胞死亡
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10901-6. doi: 10.1073/pnas.94.20.10901.
8
Glyceraldehyde-3-phosphate dehydrogenase: nuclear translocation participates in neuronal and nonneuronal cell death.甘油醛-3-磷酸脱氢酶：核转位参与神经元和非神经元细胞死亡。
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11669-74. doi: 10.1073/pnas.94.21.11669.
9
Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice.PML/RARα转基因小鼠中具有早幼粒细胞特征的急性白血病
Proc Natl Acad Sci U S A. 1997 May 13;94(10):5302-7. doi: 10.1073/pnas.94.10.5302.
10
PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.PIC 1，一种新型泛素样蛋白，它与一种多蛋白复合物的PML成分相互作用，该复合物在急性早幼粒细胞白血病中会被破坏。
Oncogene. 1996 Sep 5;13(5):971-82.

早幼粒细胞白血病蛋白与3-磷酸甘油醛脱氢酶之间RNA依赖性核相互作用的证明。

Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase.

作者信息

Carlile G W, Tatton W G, Borden K L

机构信息

Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.

出版信息

Biochem J. 1998 Nov 1;335 ( Pt 3)(Pt 3):691-6. doi: 10.1042/bj3350691.

DOI:10.1042/bj3350691
PMID:9794812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1219833/
Abstract

The promyelocytic leukaemia (protein) (PML) localizes to multiprotein complexes known as PML nuclear bodies. We found that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) co-immunoprecipitates with PML and co-localizes with PML in nuclear bodies. RNase treatment disrupts the ability of PML and GAPDH to both co-localize and co-immunoprecipitate, indicating that the association between PML and GAPDH depends on the presence of RNA. Disruption of PML bodies contributes towards reduced apoptosis in acute promyelocytic leukaemia and GAPDH induces apoptotic neuronal death. The GAPDH-PML interaction may be involved in the regulation of apoptosis.

摘要

早幼粒细胞白血病（蛋白）（PML）定位于被称为PML核体的多蛋白复合物中。我们发现，甘油醛-3-磷酸脱氢酶（GAPDH）与PML进行共免疫沉淀，并与PML在核体中共定位。核糖核酸酶处理会破坏PML和GAPDH共定位及共免疫沉淀的能力，这表明PML和GAPDH之间的关联依赖于RNA的存在。PML体的破坏导致急性早幼粒细胞白血病中细胞凋亡减少，而GAPDH可诱导凋亡性神经元死亡。GAPDH与PML的相互作用可能参与细胞凋亡的调控。