Schlüter Hartmut, Apweiler Rolf, Holzhütter Hermann-Georg, Jungblut Peter R
University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Chem Cent J. 2009 Sep 9;3:11. doi: 10.1186/1752-153X-3-11.
Our knowledge of proteins has greatly improved in recent years, driven by new technologies in the fields of molecular biology and proteome research. It has become clear that from a single gene not only one single gene product but many different ones - termed protein species - are generated, all of which may be associated with different functions. Nonetheless, an unambiguous nomenclature for describing individual protein species is still lacking. With the present paper we therefore propose a systematic nomenclature for the comprehensive description of protein species. The protein species nomenclature is flexible and adaptable to every level of knowledge and of experimental data in accordance with the exact chemical composition of individual protein species. As a minimum description the entry name (gene name + species according to the UniProt knowledgebase) can be used, if no analytical data about the target protein species are available.
近年来，在分子生物学和蛋白质组研究领域新技术的推动下，我们对蛋白质的认识有了极大的提高。很明显，从单个基因不仅可以产生一种单一的基因产物，而且可以产生许多不同的产物——称为蛋白质种类，所有这些产物可能都与不同的功能相关。然而，仍然缺乏用于描述单个蛋白质种类的明确命名法。因此，在本文中我们提出了一种系统的命名法，用于全面描述蛋白质种类。蛋白质种类命名法是灵活的，并且根据单个蛋白质种类的确切化学组成，可适应于知识和实验数据的各个层面。如果没有关于目标蛋白质种类的分析数据，作为最低限度的描述，可以使用登录名（基因名 + 根据UniProt知识库的物种名）。
