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缺氧诱导因子1：氧稳态的主要调节因子。

Hypoxia-inducible factor 1: master regulator of O2 homeostasis.

作者信息

Semenza G L

机构信息

Institute for Genetic Medicine, CMSC-1004, The Johns Hopkins UniversitySchool of Medicine, 600 N. Wolfe St., Baltimore, Maryland 21287-3914, USA.

出版信息

Curr Opin Genet Dev. 1998 Oct;8(5):588-94. doi: 10.1016/s0959-437x(98)80016-6.

DOI:10.1016/s0959-437x(98)80016-6
PMID:9794818
Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.

摘要

缺氧诱导因子1（HIF-1）是一种转录因子，介导哺乳动物对氧气供应减少的基本稳态反应。最近的研究深入探讨了HIF-1表达的氧依赖性调节、HIF-1调控的靶基因，以及HIF-1缺乏对细胞生理学和胚胎发育的影响。

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Biochem Biophys Res Commun. 1997 Nov 26;240(3):552-6. doi: 10.1006/bbrc.1997.7708.

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