CD95（APO-1/Fas）介导的细胞凋亡机制。
Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis.
作者信息
Peter M E, Krammer P H
机构信息
Tumor Immunology Program, German Cancer Research Center, Im NeuenheimerFeld 280, D-69120, Heidelberg, Germany.
出版信息
Curr Opin Immunol. 1998 Oct;10(5):545-51. doi: 10.1016/s0952-7915(98)80222-7.
PMID:9794832
Abstract
This review covers recent advances of CD95 signaling. It focuses on CD95-interacting molecules, formation of the death inducing signaling complex and the role of caspases, particularly caspase-8, and their death substrates. We also discuss the relevance of mitochondria in the CD95-mediated apoptotic process and how viral proteins interfere with crucial steps of this signaling pathway.
摘要
本综述涵盖了CD95信号传导的最新进展。它聚焦于与CD95相互作用的分子、死亡诱导信号复合物的形成以及半胱天冬酶（尤其是半胱天冬酶-8）及其死亡底物的作用。我们还讨论了线粒体在CD95介导的凋亡过程中的相关性，以及病毒蛋白如何干扰该信号通路的关键步骤。
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