Perinatal cocaine decreases the expression of prodynorphin mRNA in nucleus accumbens shell in the adult rat.

Preprodynorphin mRNA expression in the striatal-olfactory tubercle complex was studied in adult rats exposed to cocaine (50 mg/kg) during postnatal days (PnD) 11-20. While multiple regions of the striatum and olfactory tubercle were examined, alterations were only found in the nucleus accumbens. A 50% and 20% reduction in expression within the shell region was observed at 1.2 and 1.7 mm rostral to Bregma respectively. While the core regions at these levels were unaffected, the rostral accumbens showed a trend toward an increase in expression in the cocaine-treated rats. These findings, in combination with other behavioral and neurochemical data collected on similarly treated rats, suggest that perinatal cocaine produces a long-term dampening of function in a specific population of neurons within the mesolimbic system