Depraetere K, Colebunders R, Ieven M, De Droogh E, Pelgrom Y, Hauben E, Van Marck E, Devroey C
Instituut voor Tropische Geneeskunde, Departement Klinische Wetenschappen, Antwerpen.
Acta Clin Belg. 1998 Aug;53(4):255-8. doi: 10.1080/17843286.1998.11754171.
Two imported cases of Penicillium marneffei infection in Belgium are reported. Both patients are Thai women co-infected with HIV. P. marneffei infection should be suspected in immunocompromised patients originating or travelling from South-East Asia with unexplained fever (> 38 degrees C), weight loss, a generalised lymphadenopathy, hepatomegaly, splenomegaly, skin lesions, cough and anaemia. Diagnosis is made by culture and/or histopathological examination. Mild to moderate infections are treated with itraconazole 400 mg/day as first choice. Amphotericin B parenteral therapy may be required for seriously ill patients. Maintenance therapy with itraconazole 200 mg/day is necessary to prevent relapses.
报告了比利时的两例输入性马尔尼菲青霉感染病例。两名患者均为合并感染艾滋病毒的泰国女性。对于来自东南亚或曾前往东南亚且出现不明原因发热（>38摄氏度）、体重减轻、全身淋巴结肿大、肝肿大、脾肿大、皮肤病变、咳嗽及贫血的免疫功能低下患者，应怀疑马尔尼菲青霉感染。通过培养和/或组织病理学检查进行诊断。轻度至中度感染首选伊曲康唑400毫克/天进行治疗。病情严重的患者可能需要两性霉素B进行胃肠外治疗。为预防复发，必须采用伊曲康唑200毫克/天进行维持治疗。
