Kok I, Veenstra J, Rietra P J, Dirks-Go S, Blaauwgeers J L, Weigel H M
Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands.
Neth J Med. 1994 Jan;44(1):18-22.
Two cases of disseminated Penicillium marneffei infection, as an imported disease, in HIV-1-infected patients with a severe immunodeficiency are reported. These patients had a history of travel in Southeast Asia where P. marneffei is endemic. Fever, cough, malaise, hepatosplenomegaly, anaemia, skin lesions and mucosal ulcers are the main clinical characteristics. Differentiation from histoplasmosis and leishmaniasis might be difficult. Treatment with amphotericin B was successful. Anti-fungal maintenance therapy is most likely indicated.
报告了两例播散性马尔尼菲青霉感染病例，这是一种输入性疾病，发生在免疫严重缺陷的HIV-1感染患者中。这些患者有在马尔尼菲青霉流行的东南亚旅行史。发热、咳嗽、不适、肝脾肿大、贫血、皮肤病变和黏膜溃疡是主要临床特征。与组织胞浆菌病和利什曼病进行鉴别可能存在困难。两性霉素B治疗成功。极有可能需要进行抗真菌维持治疗。
