Hobson D W, Woller W, Anderson L, Guthery E
DPT Laboratories, San Antonio, TX 78215, USA.
Am J Infect Control. 1998 Oct;26(5):507-12. doi: 10.1016/s0196-6553(98)70024-0.
Since the introduction in the 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new surgical scrub formulations that have improved efficacy, persistence, or significantly improved use characteristics have not been forthcoming. In addition, the manufacturer's labeling for popular hand scrub products generally requires scrub times in excess of 6 minutes, whereas current practical needs call for products with substantially shorter scrub times. A new alcohol-based surgical scrub formulation, which has ingredients that provide emollient, surfactant, and antimicrobial persistence characteristics to complement the rapid and broad-spectrum antiseptic qualities of alcohol, has been developed in an effort to address these current practical needs.
The relative efficacy of a new alcohol-based surgical scrub formulation that contains ingredients that provide surfactant and antimicrobial persistence characteristics was compared with that of commercial 4% CHG and 7.5% povidone iodine (PVPI) formulations with use of human subjects. Hand antimicrobial count sampling was performed by using standardized "glove juice" methodology.
The efficacy and persistence results of the new formulation showed statistically significant improvement over both CHG and PVPI at a substantially lessened scrub time (3 minutes). In addition, use of the new formulation without a scrub brush produced results statistically similar to 3-minute applications with either a brush or a sponge.
The new alcohol-based formulation demonstrates promise as a new surgical hand scrub formulation with antimicrobial and use characteristics that are significantly improved over current CHG and PVPI formulations. These studies demonstrate the suitability of this formulation for use as a surgical hand scrub and for brushless application.
自20世纪70年代引入含4%葡萄糖酸氯己定（CHG）的外科洗手制剂以来，尚未出现具有更高疗效、更长持续时间或显著改善使用特性的新型外科洗手制剂。此外，流行洗手产品的制造商标签通常要求洗手时间超过6分钟，而当前的实际需求是需要洗手时间大幅缩短的产品。为满足当前实际需求，已研发出一种新型酒精基外科洗手制剂，其成分具有润肤、表面活性剂和抗菌持续特性，以补充酒精快速且广谱的抗菌特性。
使用人体受试者，将一种含有提供表面活性剂和抗菌持续特性成分的新型酒精基外科洗手制剂的相对疗效与市售4%CHG和7.5%聚维酮碘（PVPI）制剂进行比较。采用标准化的“手套液”方法进行手部抗菌计数采样。
在大幅缩短的洗手时间（3分钟）下，新制剂的疗效和持续效果在统计学上比CHG和PVPI均有显著改善。此外，不使用洗手刷使用新制剂产生的结果在统计学上与使用刷子或海绵进行3分钟涂抹的结果相似。
新型酒精基制剂有望成为一种新型外科洗手制剂，其抗菌和使用特性比目前的CHG和PVPI制剂有显著改善。这些研究证明了该制剂适用于外科洗手和免刷使用。
