Pavón N, Vidal L, Blanco L, Alvarez-Fonseca P, Torres-Montoya A, Lorigados L, Alvarez-González L, Macías R
Centro Internacional de Restauración Neurológica, CIREN, La Habana, Cuba.
Rev Neurol. 1998 Apr;26(152):554-60.
The objective of this paper was to review information related to the various factors which may trigger the mechanisms of cell death, induced or programmed, which take place in the nervous system and their relationship with the aetiopathogenesis of the neurodegenerative diseases.
In recent years it has been recognized that cell death may be not only the consequence of accidental damage but also a sign of a suicide programme. This form of death is currently known as apoptosis. It is a process which is morphologically distinct from accidental cell death or necrosis. It does not cause an inflammatory response. This type of death is not only involved in the development and haemostasis of tissues, but also in setting off neuronal degeneration in experimental models of Parkinson's disease, Huntington's chorea, etc.
In the cell death occurring in neurodegenerative diseases there is more than one induction mechanisms. Understanding the factors which trigger cell death, and the chain of events leading to this, gives grounds for the design of new pharmacological strategies for the treatment of these diseases.
本文旨在综述与可能触发神经系统中发生的诱导性或程序性细胞死亡机制的各种因素相关的信息，以及它们与神经退行性疾病病因发病机制的关系。
近年来，人们已经认识到细胞死亡不仅可能是意外损伤的结果，也是自杀程序的一个标志。这种死亡形式目前被称为凋亡。它是一个在形态上与意外细胞死亡或坏死不同的过程。它不会引起炎症反应。这种类型的死亡不仅参与组织的发育和止血，还在帕金森病、亨廷顿舞蹈症等实验模型中引发神经元变性。
在神经退行性疾病中发生的细胞死亡存在多种诱导机制。了解触发细胞死亡的因素以及导致细胞死亡的一系列事件，为设计治疗这些疾病的新药理学策略提供了依据。
