Nozawa T, Inoue H
Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University.
Nihon Rinsho. 1998 Oct;56(10):2612-6.
The effects of beta-blockers on acute myocardial infarction can be divided into those that are immediate and long-term (secondary prevention). beta-blockers given early in the course of infarction may diminish myocardial oxygen demand and therefore reduce chest pain and infarct size. Many clinical trials have clearly shown that both early and long-term treatment with beta-blockers reduce cardiac mortality and the rate of re-infarction. As seen in recommendations of ACC (American College of Cardiology)/AHA (American Heart Association) guidelines for management of acute myocardial infarction, all patients without a contraindication to beta-blockers should be treated with beta-blockers from very early course of the onset and be continued indefinitely.
β受体阻滞剂对急性心肌梗死的作用可分为即刻作用和长期作用（二级预防）。在梗死病程早期给予β受体阻滞剂可降低心肌需氧量，从而减轻胸痛并缩小梗死面积。许多临床试验已明确表明，β受体阻滞剂的早期和长期治疗均可降低心脏死亡率和再梗死率。正如美国心脏病学会（ACC）/美国心脏协会（AHA）急性心肌梗死管理指南的建议所示，所有无β受体阻滞剂禁忌证的患者均应在发病早期即开始接受β受体阻滞剂治疗，并持续无限期使用。
