Kodama K, Hirayama A
Cardiovascular Division, Osaka Police Hospital.
Nihon Rinsho. 1998 Oct;56(10):2659-65.
The rupture of the unstable plaque and the thrombus formation caused the occlusion of the coronary artery and followed myocardial ischemia and/or myocardial necrosis, then resulted in clinical worse outcome. The reopen of the occluded artery is the most important things for the treatment of acute coronary syndrome, and there are usually two established ways to open the occluded artery. Thrombolysis and angioplasty are already established ways to reopen, however has some complications, that is, failure to reopen, reocclusion, and bleeding. Angioscopic observations reveal the mechanism underlying these complications and suggest that platelet rich white thrombus formation continues until a month after the onset and unstable yellow plaques exist until 18 months after the onset. The most problems for the treatment in today are the unaware of the mechanism of the occlusion. If the thrombus is the major mechanism for the occlusion, thrombolytic therapy must be chosen. If the plaque is the major occlusive mechanism, the angioplasty must be chosen. To reveal the mechanisms underlying the coronary artery occlusion, we will have to use the angioscope instead of coronary angiography. After we will be able to clarify the occlusive mechanism by angioscope, we will reduce the dosage of thrombolytic agents and resulted in the decrement of bleeding complications and reopen the coronary artery effectively without complications.
不稳定斑块破裂和血栓形成导致冠状动脉闭塞,继而引发心肌缺血和/或心肌坏死,进而导致临床预后恶化。开通闭塞动脉是急性冠状动脉综合征治疗的关键,目前通常有两种成熟的开通方法。溶栓和血管成形术是已确立的开通方法,但存在一些并发症,即开通失败、再闭塞和出血。血管内镜观察揭示了这些并发症的潜在机制,并表明富含血小板的白色血栓形成可持续至发病后一个月,不稳定的黄色斑块可持续至发病后18个月。目前治疗中最大的问题是不清楚闭塞机制。如果血栓是闭塞的主要机制,就必须选择溶栓治疗。如果斑块是主要的闭塞机制,则必须选择血管成形术。为了揭示冠状动脉闭塞的潜在机制,我们必须使用血管内镜而非冠状动脉造影。当我们能够通过血管内镜阐明闭塞机制后,我们将减少溶栓药物的用量,从而减少出血并发症,并有效开通冠状动脉且无并发症。