Karasuno T, Nakamura H, Fukuda H, Okajima Y, Maeda T, Teshima H, Hiraoka A, Masaoka T
Fifth Department of Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases.
Rinsho Ketsueki. 1998 Sep;39(9):716-8.
We analyzed the distribution of two T cell subsets, CD8+ CD11a+ (CD8+ cytotoxic effector population) and CD8+ CD57- cells, in the peripheral lymphocytes of 3 post-operative patients with post-transfusion graft-versus-host disease (PT-GVHD) and 5 post-operative patients without PT-GVHD. The percentage of CD8+ CD11a+ cells in the PT-GVHD-negative control was 19 +/- 4%, and in the 3 patients with PT-GVHD, 69%, 66%, and 59%, respectively. The percentage of CD8+ CD57- cells in the PT-GVHD-negative control was 19 +/- 6%, and in the 3 PT-GVHD patients, 59%, 58%, and 55%, respectively. Significantly higher proportions of the two T cell subsets were consistently observed in the patients with PT-GVHD than in the PT-GVHD-negative control. These results suggest that the analysis of CD8+ T cell subsets may be useful for the simple and rapid laboratory diagnosis of PT-GVHD.
我们分析了3例输血后移植物抗宿主病（PT - GVHD）术后患者和5例无PT - GVHD术后患者外周淋巴细胞中两种T细胞亚群，即CD8 + CD11a +（CD8 + 细胞毒性效应细胞群）和CD8 + CD57 - 细胞的分布情况。PT - GVHD阴性对照组中CD8 + CD11a + 细胞的百分比为19±4%，而在3例PT - GVHD患者中，分别为69%、66%和59%。PT - GVHD阴性对照组中CD8 + CD57 - 细胞的百分比为19±6%，而在3例PT - GVHD患者中，分别为59%、58%和55%。与PT - GVHD阴性对照组相比，PT - GVHD患者中这两种T细胞亚群的比例始终显著更高。这些结果表明，CD8 + T细胞亚群的分析可能有助于PT - GVHD的简单快速实验室诊断。
