Yan Q C, Tomita N, Ikada Y
Institute for Frontier Medical Sciences, Kyoto University, Japan.
Med Eng Phys. 1998 Sep;20(6):397-402. doi: 10.1016/s1350-4533(98)00051-4.
Effects of static magnetic fields (SMF) on bone formation of rat femurs, were evaluated using tapered rods made of magnetized and unmagnetized samarium cobalt of the same size. They were implanted transcortically into the middle diaphysis of rat femurs under press-fit loading. The bone mineral density (BMD) and bone calcium content were measured 12 weeks after implantation by dual-energy X-ray absorptiometry and chemical analysis with o-cresolphthalein complexon, respectively. The result revealed that the femurs adjacent to magnetized specimens had significantly higher BMD and calcium content than those adjacent to the unmagnetized specimen (p < 0.01). However, the value of BMD and calcium content of rats with magnetized specimens was similar to that of non-operated rats. No specific change was found in the body weight, serum Ca, activity of alkaline phosphatase, hemogram, and BMD of the tibia and humerus among the magnetized and unmagnetized. These results suggest that the long-term local SMF stimulation on the bone has a local effect to prevent the decrease in BMD caused by surgical invasion or implantation.
使用相同尺寸的磁化和未磁化钐钴制成的锥形棒，评估静磁场（SMF）对大鼠股骨骨形成的影响。将它们在压配合负载下经皮质植入大鼠股骨的中骨干。分别在植入12周后通过双能X线吸收法和邻甲酚酞络合化学分析法测量骨矿物质密度（BMD）和骨钙含量。结果显示，与磁化标本相邻的股骨的BMD和钙含量显著高于与未磁化标本相邻的股骨（p<0.01）。然而，有磁化标本的大鼠的BMD和钙含量值与未手术大鼠相似。在磁化和未磁化的大鼠中，体重、血清钙、碱性磷酸酶活性、血常规以及胫骨和肱骨的BMD均未发现特异性变化。这些结果表明，对骨的长期局部SMF刺激具有局部作用，可防止因手术侵袭或植入导致的BMD降低。
