Yang Ke, Wu Zhuoshu, Zhang Keke, Weir Michael D, Xu Hockin H K, Cheng Lei, Huang Xiaojing, Zhou Wen
Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
Front Pharmacol. 2024 Jul 31;15:1437457. doi: 10.3389/fphar.2024.1437457. eCollection 2024.
Bone defects caused by tumors, osteoarthritis, and osteoporosis attract great attention. Because of outstanding biocompatibility, osteogenesis promotion, and less secondary infection incidence ratio, stimuli-responsive biomaterials are increasingly used to manage this issue. These biomaterials respond to certain stimuli, changing their mechanical properties, shape, or drug release rate accordingly. Thereafter, the activated materials exert instructive or triggering effects on cells and tissues, match the properties of the original bone tissues, establish tight connection with ambient hard tissue, and provide suitable mechanical strength. In this review, basic definitions of different categories of stimuli-responsive biomaterials are presented. Moreover, possible mechanisms, advanced studies, and pros and cons of each classification are discussed and analyzed. This review aims to provide an outlook on the future developments in stimuli-responsive biomaterials.
由肿瘤、骨关节炎和骨质疏松症引起的骨缺损备受关注。由于具有出色的生物相容性、促进骨生成以及较低的继发感染发生率，刺激响应性生物材料越来越多地被用于解决这一问题。这些生物材料对特定刺激做出反应，相应地改变其机械性能、形状或药物释放速率。此后，活化的材料对细胞和组织发挥指导或触发作用，匹配原始骨组织的特性，与周围硬组织建立紧密连接，并提供合适的机械强度。在本综述中，介绍了不同类别的刺激响应性生物材料的基本定义。此外，还对每种分类的可能机制、前沿研究以及优缺点进行了讨论和分析。本综述旨在展望刺激响应性生物材料的未来发展。
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