Xu S, Tomita N, Ohata R, Yan Q, Ikada Y
Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.
Biomed Mater Eng. 2001;11(3):257-63.
Effects of a static magnetic field were studied on bone formation using an ischemic rat femur model. Metal rods were prepared from magnetized and unmagnetized samariun cobalt to have tapered structure, both with the same geometrical dimension, and were implanted transcortically into the middle diaphysis of 88 rat femurs. Both sides of the rat femoral artery were ligated to create an ischemic bone model, followed by implantation of the tapered rod to the femur. The bone mineral density (BMD) and weight of the femurs were measured at 1st and 3rd week after implantation. The result at the 3rd week post-implantation revealed that the BMD and weight of the ischemic bone model rats were significantly reduced, compared with that of non-operated femur. It was also found that the magnetized group had significantly higher bone weights than the unmagnetized (p<0.05). The BMD of the rats implanted with the magnetized rods were similar to those of the non-operated (p>0.05). This enhancement of the femoral bone formation of the ischemic rat model by the static magnetic field seems to be due to the improved blood circulation of the femur.
使用缺血性大鼠股骨模型研究了静磁场对骨形成的影响。用磁化和未磁化的钐钴制备金属棒，使其具有锥形结构，两者几何尺寸相同，并经皮质植入88只大鼠股骨的中骨干。结扎大鼠股动脉两侧以建立缺血性骨模型，然后将锥形棒植入股骨。在植入后第1周和第3周测量股骨的骨矿物质密度（BMD）和重量。植入后第3周的结果显示，与未手术的股骨相比，缺血性骨模型大鼠的BMD和重量显著降低。还发现磁化组的骨重量明显高于未磁化组（p<0.05）。植入磁化棒的大鼠的BMD与未手术的大鼠相似（p>0.05）。静磁场对缺血性大鼠模型股骨骨形成的这种增强作用似乎是由于股骨血液循环的改善。
