卵巢癌患者的血清白细胞介素1

Serum interleukin 1 in ovarian cancer patients.

作者信息

Zeisler H, Tempfer C, Joura E A, Sliutz G, Koelbl H, Wagner O, Kainz C

机构信息

Department of Gynaecology and Obstetrics, University of Vienna Medical School, General Hospital Vienna, Austria.

出版信息

Eur J Cancer. 1998 May;34(6):931-3. doi: 10.1016/s0959-8049(97)10107-1.

DOI:10.1016/s0959-8049(97)10107-1

PMID:9797710

Abstract

Interleukin-1 (IL-1) is a multifunctional cytokine playing a central role in the immune response and displaying direct cytotoxic activity in vitro. Serum IL-1 alpha and beta levels were measured by enzyme linked immunosorbent assay (ELISA) in 75 ovarian cancer patients, 30 patients with benign ovarian cysts and 50 healthy controls. Both serum IL-1 alpha and IL-1 beta levels were more often elevated in ovarian cancer patients compared with healthy controls (chi-square test, P < 0.001 and P < 0.001, respectively). Mean serum IL-1 alpha and beta levels decreased significantly after surgical intervention (paired t-test, P = 0.0001 and P = 0.0002, respectively). No correlation with histopathological parameters and overall and disease-free survival was found. These preliminary results indicate that serum levels of IL-1 alpha and beta represent a host defence reaction rather than an autonomous tumour cell production.

摘要

白细胞介素-1（IL-1）是一种多功能细胞因子，在免疫反应中起核心作用，并在体外表现出直接的细胞毒性活性。通过酶联免疫吸附测定（ELISA）测量了75例卵巢癌患者、30例良性卵巢囊肿患者和50例健康对照者血清IL-1α和β水平。与健康对照相比，卵巢癌患者血清IL-1α和IL-1β水平升高更为常见（卡方检验，P分别<0.001和<0.001）。手术干预后，血清IL-1α和β平均水平显著下降（配对t检验，P分别=0.0001和0.0002）。未发现与组织病理学参数以及总生存期和无病生存期相关。这些初步结果表明，血清IL-1α和β水平代表宿主防御反应，而非肿瘤细胞自主产生。