Jenkin G A, Tee W
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Victoria, Australia.
Clin Infect Dis. 1998 Oct;27(4):816-21. doi: 10.1086/514957.
Campylobacter upsaliensis was isolated from the feces of 20 human immunodeficiency virus (HIV)-infected patients with diarrhea over a 67-month period, representing 18.5% of fecal Campylobacter isolates from our HIV-seropositive patients. All isolates were recovered from feces by a 0.45-micron-membrane filtration method. Culture on Skirrow's selective medium incubated at 42 degrees C failed to support any growth. The mean CD4 cell count of the patient group was 185/mm3 (range, 0-840/mm3), and all patients had diarrhea for 1-60 days (mean, 19 days). Thirteen had no other enteric pathogen isolated, and three patients (CD4 counts, < or = 70/mm3) had persistent carriage for between 5 weeks and 3 months. All tested isolates were susceptible to erythromycin and doxycycline, but three isolates from two patients were resistant to ciprofloxacin. C. upsaliensis is associated with prolonged diarrhea of mild to moderate severity in HIV-infected patients.
在67个月的时间里，从20例腹泻的人类免疫缺陷病毒（HIV）感染患者的粪便中分离出了乌普萨拉弯曲菌，占我们HIV血清阳性患者粪便弯曲菌分离株的18.5%。所有分离株均通过0.45微米膜过滤法从粪便中回收。在42℃孵育的斯金罗（Skirrow）选择性培养基上培养未能支持任何生长。患者组的平均CD4细胞计数为185/mm³（范围为0 - 840/mm³），所有患者腹泻1 - 60天（平均19天）。13例未分离出其他肠道病原体，3例患者（CD4计数≤70/mm³）持续携带该菌5周至3个月。所有检测的分离株对红霉素和强力霉素敏感，但来自两名患者的3株分离株对环丙沙星耐药。乌普萨拉弯曲菌与HIV感染患者轻度至中度严重程度的长期腹泻有关。
