Isogai Z, Sunohara A, Tsuji T
Department of Dermatology, Nagoya City University Medical School, Japan.
J Dermatol. 1998 Sep;25(9):612-5. doi: 10.1111/j.1346-8138.1998.tb02467.x.
We report a case of pustular drug eruption due to bacampicilin hydrochloride which developed in a patient with pustular psoriasis. The patient was a 45-year-old Japanese woman with psoriasis which started as pustular psoriasis twenty years previously. In 1994, she developed generalized erythema with pustules accompanied by high fever and liver injury. Clinical and histological findings of this pustular eruption were different from her previous episodes of pustular psoriasis. Erythemas and pustules disappeared and her abnormal transaminase returned to normal rapidly when she discontinued bacampicilin hydrochloride. Her positive reaction to a patch test and a lymphocyte stimulation test also suggested that our case had a pustular drug eruption rather than pustular psoriasis induced by a drug.
我们报告一例因盐酸巴氨西林引起的脓疱性药疹，该患者患有脓疱型银屑病。患者为一名45岁的日本女性，银屑病始于20年前的脓疱型银屑病。1994年，她出现全身红斑伴脓疱，伴有高热和肝损伤。此次脓疱性皮疹的临床和组织学表现与她之前的脓疱型银屑病发作不同。当她停用盐酸巴氨西林后，红斑和脓疱消失，异常转氨酶迅速恢复正常。她对斑贴试验和淋巴细胞刺激试验的阳性反应也表明，我们的病例是脓疱性药疹，而非药物诱发的脓疱型银屑病。
