Betke H, Korabiowska M, Brinck U, Trybus-Gałuszka H, Kellner S, Okoń K, Stachura J, Droese M
Department of Cytopathology, Georg-August University, Goettingen, Germany.
Pol J Pathol. 1998;49(2):93-6.
The nm23 monoclonal antibody directed to specific antigen was applied for investigation of 29 benign naevi, 59 melanomas of different Clark level and locations, 4 lymph node and 28 organ metastases, using quantitative immunohistochemistry. The reduced expression of nm23 protein was associated with the tumor progression. A statistically significant difference (p = 0.0014) was found in nm23 protein expression between naevi and malignant melanomas. Additionally, a reduced protein level in metastases was found. A strong correlation was found between nm23 expression and survival of patients as well as the presence of metastasis (p = 0.0003).
采用定量免疫组化方法，将针对特定抗原的nm23单克隆抗体应用于29例良性痣、59例不同Clark分级和部位的黑色素瘤、4例淋巴结转移及28例器官转移的研究。nm23蛋白表达降低与肿瘤进展相关。在痣与恶性黑色素瘤之间，nm23蛋白表达存在统计学显著差异（p = 0.0014）。此外，转移灶中的蛋白水平降低。nm23表达与患者生存率及转移情况之间存在强相关性（p = 0.0003）。
