McDermott N C, Milburn C, Curran B, Kay E W, Barry Walsh C, Leader M B
Department of Histopathology, Royal College of Surgeons in Ireland, Dublin, Ireland.
J Pathol. 2000 Feb;190(2):157-62. doi: 10.1002/(SICI)1096-9896(200002)190:2<157::AID-PATH512>3.0.CO;2-J.
The objective of this study was to determine the utility of nm23 as an immunohistochemical indicator of prognosis in a large series (157 cases) of malignant melanoma and also in two subsets within this group: stage 1 tumours, whether in radial or vertical growth phase (140 cases); and stage 1 tumours in which a vertical growth phase component was positively identified (123 cases). A secondary objective was to explore the relationship between the immunohistochemical expression of nm23 and established clinical and histological indicators of prognosis in each of these three groups. In all groups it was found that strong immunoreactivity correlated positively with survival and inversely with indicators of poor prognosis, in keeping with transfection and mRNA studies and also with many immunohistochemical studies of other tumour types. That these findings are at variance with earlier reported immunohistochemical studies of melanoma highlights the importance of large case numbers of primary invasive tumours in studies which set out to explore the relationship between immunoreactivity and survival.
本研究的目的是确定nm23作为免疫组织化学指标在一大系列（157例）恶性黑色素瘤预后评估中的效用，同时也在该组中的两个亚组中进行评估：处于放射状或垂直生长期的Ⅰ期肿瘤（140例）；以及已明确鉴定出存在垂直生长期成分的Ⅰ期肿瘤（123例）。第二个目的是探讨nm23的免疫组织化学表达与这三组中各自既定的临床和组织学预后指标之间的关系。在所有组中均发现，强免疫反应性与生存率呈正相关，与预后不良指标呈负相关，这与转染和mRNA研究以及许多其他肿瘤类型的免疫组织化学研究结果一致。这些发现与早期报道的黑色素瘤免疫组织化学研究结果不同，这突出了在旨在探索免疫反应性与生存率之间关系的研究中纳入大量原发性浸润性肿瘤病例的重要性。
