复发性自然流产风险、吸烟与NAT2和GSTM1基因多态性
Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1.
作者信息
Mendola P, Moysich K B, Freudenheim J L, Shields P G, Schisterman E F, Graham S, Vena J E, Marshall J R, Ambrosone C B
机构信息
Department of Social and Preventive Medicine, University at Buffalo, NY, USA.
出版信息
Epidemiology. 1998 Nov;9(6):666-8.
Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.
孕妇吸烟会增加自然流产的风险。多态性N-乙酰转移酶（NAT2）和谷胱甘肽S-转移酶（GSTM1）会影响烟草烟雾中某些诱变剂的代谢。对至少有两次自然流产的女性（N = 32）和至少有两次活产的女性（N = 179）的基因型和吸烟情况进行了研究。吸烟会轻微增加风险（优势比 = 1.3；95%置信区间 = 0.6 - 2.9），但NAT2和GSTM1不会。NAT2或GSTM1基因多态性不会明显改变与吸烟相关的风险。
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