小鼠短尾基因二号（T2）是紧邻经典T基因的一个基因，也是tct的候选基因。
Mouse Brachyury the Second (T2) is a gene next to classical T and a candidate gene for tct.
作者信息
Rennebeck G, Lader E, Fujimoto A, Lei E P, Artzt K
机构信息
The Institute for Cellular and Molecular Biology, Department of Microbiology, The University of Texas, Austin, Texas 78712-1064, USA.
出版信息
Genetics. 1998 Nov;150(3):1125-31. doi: 10.1093/genetics/150.3.1125.
The mouse Brachyury the Second (T2) gene is 15 kb away from classical Brachyury (T). A mutation in T2 disrupts notochord development, pointing to the existence of a second T/t complex gene involved in axis development. T2 encodes a novel protein that is disrupted by an insertion in T2(Bob) mice. Sequence analysis of T2 from several t haplotypes shows that they all share the same changed stop codon, and, thus, T2 is a candidate gene for the t complex tail interaction factor. T1, T2, and the unlinked t-int are distinct and unrelated loci, and mutations in these genes do not complement one another genetically. Either their products interact in the same pathway during the genesis of the embryonic axis, or the T/t region itself is truly complex.
小鼠短尾第二（T2）基因距离经典短尾（T）基因15千碱基对。T2基因的突变会破坏脊索发育，这表明存在第二个参与轴发育的T/t复合基因。T2编码一种新蛋白质，该蛋白质在T2（Bob）小鼠中因插入而被破坏。对几种t单倍型的T2进行序列分析表明，它们都共享相同的改变后的终止密码子，因此，T2是t复合尾部相互作用因子的候选基因。T1、T2和不连锁的t-int是不同且不相关的基因座，这些基因中的突变在遗传上不能相互互补。要么它们的产物在胚胎轴形成过程中在同一途径中相互作用，要么T/t区域本身确实是复杂的。
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