del Rey J M, Madrid A H, Valiño J M, Rubí J, Mercader J, Moro C, Ripoll E
Clinical Biochemistry Department, Ramón y Cajal Hospital, Alcalá University, Madrid, Spain.
Clin Chem. 1998 Nov;44(11):2270-6.
Radiofrequency (RF) catheter ablation is the curative treatment of choice for many cardiac arrhythmias. After RF ablation there is always a small localized endomyocardial necrosis, necessary to abolish the arrhythmia. We designed this study to determine the serum concentrations of several cardiac markers in patients who underwent RF catheter ablation. The study shows a higher frequency of increase of serum cardiac troponin I (cTnI) than of creatine kinase (CK), the CK MB isoenzyme (CK-MB), or myoglobin. A pathological value of cTnI was found in 47 of 51 patients (92%) in the ablation group. The area under the ROC curve for cTnI was 0.9375, significantly higher than for the other biochemical markers (0.86, 0.76, and 0.75 for CK-MB, myoglobin, and CK, respectively), with P <0.05. We conclude that the serum concentration of cTnI is the best biochemical marker for detecting the minor myocardial damage produced by RF ablation.
射频（RF）导管消融术是治疗多种心律失常的首选根治性方法。射频消融术后总会出现小范围的局限性心内膜心肌坏死，这对于消除心律失常是必要的。我们设计了这项研究，以确定接受射频导管消融术患者的几种心脏标志物的血清浓度。研究表明，血清心肌肌钙蛋白I（cTnI）升高的频率高于肌酸激酶（CK）、CK的MB同工酶（CK-MB）或肌红蛋白。消融组51例患者中有47例（92%）的cTnI值呈病理性升高。cTnI的ROC曲线下面积为0.9375，显著高于其他生化标志物（CK-MB、肌红蛋白和CK的曲线下面积分别为0.86、0.76和0.75），P<0.05。我们得出结论，cTnI的血清浓度是检测射频消融所致轻微心肌损伤的最佳生化标志物。
