在遭受耳毒性损伤的龙猫中，畸变产物耳声发射和瞬态诱发耳声发射与听性脑干反应阈值变化的比较。

Comparison of distortion-product and transient evoked otoacoustic emissions with ABR threshold shift in chinchillas with ototoxic damage.

作者信息

Kakigi A, Hirakawa H, Harel N, Mount R J, Harrison R V

机构信息

Department of Otolaryngology, Hospital for Sick Children, University of Toronto, Canada.

出版信息

Auris Nasus Larynx. 1998 Sep;25(3):223-32. doi: 10.1016/s0385-8146(98)00034-0.

DOI:10.1016/s0385-8146(98)00034-0

PMID:9799987

Abstract

In this study we compare distortion product otoacoustic emissions (DPOAEs), transient evoked otoacoustic emissions (TEOAEs) and ABR threshold shifts in an animal model (chinchilla) of cochlear hearing loss. Subjects were treated with an aminoglycoside (amikacin) to produce basal cochlear lesions of various degree. DPOAE and TEOAE were measured throughout the treatment period and until hearing thresholds stabilized. ABR thresholds to tone pip stimuli were determined. Cytocochleograms of cochleas were prepared using scanning microscopy. DPOAEs (2f1-f2) were compared to fast Fourier transform (FFT)-analyzed TEOAEs components in the 1-, 2-, and 4-kHz frequency regions. Both types of emission were compared with corresponding ABR thresholds. There was no significant linear correlation between these different measures of cochlear function. Moreover, the amplitudes of DPOAEs reflected smaller regions of cochlear outer hair cell (OHC) damage better than TEOAEs. These results suggest that DPOAEs can be used to more accurately monitor hair cell function at specific hearing locations than TEOAEs.

摘要

在本研究中，我们比较了在耳蜗性听力损失动物模型（栗鼠）中畸变产物耳声发射（DPOAE）、瞬态诱发耳声发射（TEOAEs）和听性脑干反应（ABR）阈值变化。实验对象接受氨基糖苷类药物（阿米卡星）治疗以产生不同程度的耳蜗基底病变。在整个治疗期间直至听力阈值稳定，测量DPOAE和TEOAEs。测定对短纯音刺激的ABR阈值。使用扫描显微镜制备耳蜗的细胞耳蜗图。在1千赫、2千赫和4千赫频率区域，将DPOAEs（2f1 - f2）与经快速傅里叶变换（FFT）分析的TEOAEs成分进行比较。将这两种耳声发射类型与相应的ABR阈值进行比较。耳蜗功能的这些不同测量指标之间不存在显著的线性相关性。此外，与TEOAEs相比，DPOAEs的振幅能更好地反映耳蜗外毛细胞（OHC）较小区域的损伤情况。这些结果表明，与TEOAEs相比，DPOAEs可用于更准确地监测特定听力部位的毛细胞功能。