de Visme P G
Ugeskr Laeger. 1998 Oct 12;160(42):6088-91.
Ingestion of the increasingly popular designer drug, ecstasy, results in an acute increase in the brain's monoamines: serotonin, dopamine, and noradrenaline. Animal research involving ecstasy has shown lasting damage to serotonergic axons and terminals, leading to reduced serotonin transmission in the CNS. Moreover, several studies suggest that the ingestion of ecstasy may be toxic to the human serotonin system. In animals repeated ecstasy administration has not shown persistent behavioural changes. In humans long lasting alterations in sleep pattern, mental state, personality, and cognition have been reported after repeated ecstasy use. However, these results have not been replicated, and most of them originate from uncontrolled studies of rather small populations.
摄入越来越流行的合成毒品摇头丸会导致大脑中的单胺类物质（血清素、多巴胺和去甲肾上腺素）急剧增加。涉及摇头丸的动物研究表明，血清素能轴突和终末会受到持久性损伤，导致中枢神经系统中血清素传递减少。此外，多项研究表明，摄入摇头丸可能对人类血清素系统有毒性。在动物身上，重复给予摇头丸并未显示出持续的行为变化。在人类中，据报道，重复使用摇头丸后会出现睡眠模式、精神状态、个性和认知方面的长期改变。然而，这些结果尚未得到重复验证，而且其中大多数源于对相当小群体的非对照研究。
