Nickel J C, Siemens D R, Johnston B
Department of Urology, Queen's University, Kingston General Hospital, Ontario, Canada.
Tech Urol. 1998 Sep;4(3):128-30.
There is no universally successful therapy for chronic nonbacterial prostatitis. Successful outcomes of treatment have been independently reported with transurethral heat therapy and balloon dilation. The THERP transurethral "hot balloon" uses balloon dilation of the prostatic urethra and radiofrequency heating of the prostate. Patients with refractory chronic nonbacterial prostatitis were assessed with validated prostatitis-specific symptom indices prior to, 3, and 6 months after 900 seconds of THERP treatment. Although early results appeared promising the long-term results in four patients led to early termination of the study. Although one patient did have improvement at 6 months, no patient reported improvement at 9 months, and the adverse events (urinary retention, retrograde ejaculation, hematuria, urethral stricture, worsening of symptoms) of this treatment in prostatitis patients was significant. This study demonstrated no sustainable efficacy and substantial adverse effects for the use of combination balloon dilation and heat therapy for patients with chronic nonbacterial prostatitis.
对于慢性非细菌性前列腺炎，目前尚无普遍成功的治疗方法。经尿道热疗和球囊扩张术已分别有治疗成功的报道。THERP经尿道“热球囊”利用前列腺尿道的球囊扩张和前列腺的射频加热。对难治性慢性非细菌性前列腺炎患者在接受THERP治疗900秒之前、治疗后3个月和6个月，使用经过验证的前列腺炎特异性症状指标进行评估。尽管早期结果看起来很有希望，但4例患者的长期结果导致该研究提前终止。虽然有1例患者在6个月时有改善，但没有患者在9个月时报告有改善，而且这种治疗在前列腺炎患者中的不良事件（尿潴留、逆行射精、血尿、尿道狭窄、症状恶化）很显著。这项研究表明，联合球囊扩张和热疗用于慢性非细菌性前列腺炎患者没有可持续的疗效，且有大量不良反应。
