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随着产妇年龄的增加,产科干预的风险是否会逐步上升?

Is there an incremental rise in the risk of obstetric intervention with increasing maternal age?

作者信息

Rosenthal A N, Paterson-Brown S

机构信息

Queen Charlotte's and Chelsea Hospital for Women, London, UK.

出版信息

Br J Obstet Gynaecol. 1998 Oct;105(10):1064-9. doi: 10.1111/j.1471-0528.1998.tb09937.x.

Abstract

OBJECTIVE

To determine whether increasing maternal age increases the risk of operative delivery and to investigate whether such a trend is due to fetal or maternal factors. DESIGN ANALYSIS: of prospectively collected data on a maternity unit database.

SETTING

A postgraduate teaching hospital.

POPULATION

6410 nulliparous women with singleton cephalic pregnancies delivering at term (3742 weeks of gestation) between 1 January 92 and 31 December 95.

MAIN OUTCOME MEASURES

Mode of delivery, rates of prelabour caesarean section, induction of labour and epidural usage.

RESULTS

There was a positive, highly significant association between increasing maternal age and obstetric intervention. Prelabour (P < 0.001) and emergency (P < 0.001) caesarean section, instrumental vaginal delivery (spontaneous labour P < 0001; induced labour P = 0.001), induction of labour (P < 0.001) and epidural usage in spontaneous labour (P = 0.005) all increased with increasing age. In the second stage of labour fetal distress and failure to advance, requiring instrumental delivery, were both more likely with increasing maternal age (in both P < 0.001). Epidural usage in induced labour and the incidence of small for gestational age newborns did not increase with increasing maternal age (P = 0.68 and P = 0.50, respectively).

CONCLUSIONS

This study demonstrates that increasing maternal age is associated with an incremental increase in obstetric intervention. Previous studies have demonstrated a significant effect in women older than 35 years of age, but these data show changes on a continuum from teenage years. This finding may reflect a progressive, age-related deterioration in myometrial function.

摘要

目的

确定产妇年龄增加是否会增加手术分娩的风险,并调查这种趋势是否归因于胎儿或母体因素。设计分析:对前瞻性收集的产科病房数据库中的数据进行分析。

地点

一家研究生教学医院。

研究对象

1992年1月1日至1995年12月31日期间,6410名单胎头位妊娠的初产妇足月(妊娠37 - 42周)分娩。

主要观察指标

分娩方式、临产前剖宫产率、引产率和硬膜外麻醉使用率。

结果

产妇年龄增加与产科干预之间存在正相关且高度显著。临产前剖宫产(P < 0.001)、急诊剖宫产(P < 0.001)、器械助产阴道分娩(自然分娩P < 0.001;引产P = 0.001)、引产(P < 0.001)以及自然分娩时硬膜外麻醉使用率(P = 0.005)均随年龄增加而上升。在第二产程中,随着产妇年龄增加,胎儿窘迫和产程无进展而需器械助产的可能性均增加(两者P均 < 0.001)。引产时硬膜外麻醉使用率以及小于胎龄新生儿的发生率并未随产妇年龄增加而上升(分别为P = 0.68和P = 0.50)。

结论

本研究表明,产妇年龄增加与产科干预的逐步增加相关。既往研究表明35岁以上女性有显著影响,但这些数据显示从青少年时期起就有连续变化。这一发现可能反映了子宫肌层功能随年龄增长而逐渐恶化。

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