Hoorweg J J, Hilgers F J, Keus R B, Zoetmulder F A, Loftus B M
Department of Otolaryngology-Head & Neck Surgery, The Netherlands Cancer Institute/Antoni van Leeuwenhoek ziekenhuis, Amsterdam.
Eur J Surg Oncol. 1998 Oct;24(5):452-5. doi: 10.1016/s0748-7983(98)92651-8.
Three cases of metastasizing pleomorphic adenoma are described. All three had a history of incomplete surgery of the primary tumour and several surgical procedures for local recurrences before systemic metastases became apparent. The histology of the primary tumour, recurrences and metastases were typical of pleomorphic adenoma. In view of the lack of information in the literature, it is concluded that inadequate surgical procedures, such as incomplete surgery or enucleation, leading to multiple recurrences, appear to be a prerequisite for the development of systemic disease.
本文描述了三例转移性多形性腺瘤。所有三例患者均有原发肿瘤手术不彻底的病史，在出现全身转移之前，因局部复发进行了多次手术。原发肿瘤、复发灶和转移灶的组织学表现均为典型的多形性腺瘤。鉴于文献中缺乏相关信息，得出的结论是，不充分的手术操作，如手术不彻底或剜除术，导致多次复发，似乎是全身性疾病发生的先决条件。
