Temple H T, Mizel M S, Murphey M D, Sweet D E
Department of Orthopaedic Surgery, The University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Foot Ankle Int. 1998 Oct;19(10):698-704. doi: 10.1177/107110079801901009.
A total of 329 patients with osteoblastoma were retrospectively reviewed from the archives of the Armed Forces Institute of Pathology, of which 41 (12.5%) presented with tumors in the foot and ankle. This was the third most common site of disease after the spine and femur. Overall, the mean age was 22.5 years, which was the same for the foot and ankle subset of patients; however, there was a significant male predominance in foot and ankle patients compared with the whole group. The majority of patients were skeletally mature (85.4%). Clinically, most patients presented with pain (97.2%), although one-third of the total related a history of antecedent trauma. The interval between the onset of symptoms and biopsy was 84 days (range, 0-572 days). Radiographically, the majority of lesions were in the hindfoot (N = 18; 44%) of which 16 of 18 tumors (89%) were in the talus. Of these, one-half were subperiosteal and dorsally based and were associated with osseous tumor matrix and a soft tissue mass. Two osteoblastomas, both in the metatarsals, transitioned into sarcomas; the rest were histologically benign. For diagnostic purposes, it was essential to obtain clinical, radiographic, and histologic correlation.
从武装部队病理研究所的档案中对总共329例骨母细胞瘤患者进行了回顾性研究，其中41例（12.5%）足部和踝关节出现肿瘤。这是仅次于脊柱和股骨的第三大常见发病部位。总体而言，平均年龄为22.5岁，足部和踝关节患者亚组也是如此；然而，与整个组相比，足部和踝关节患者中男性占比显著更高。大多数患者骨骼成熟（85.4%）。临床上，大多数患者表现为疼痛（97.2%），尽管总数的三分之一有既往创伤史。症状出现至活检的间隔时间为84天（范围0 - 572天）。影像学上，大多数病变位于后足（N = 18；44%），其中18个肿瘤中有16个（89%）位于距骨。其中，一半为骨膜下且位于背侧，伴有骨肿瘤基质和软组织肿块。2例骨母细胞瘤均位于跖骨，后来转变为肉瘤；其余组织学上为良性。为了诊断目的，获得临床、影像学和组织学的相关性至关重要。
