Rokkas C K, Kouchoukos N T
Heart Center, Missouri Baptist Medical Center, St Louis, MO, USA.
Semin Thorac Cardiovasc Surg. 1998 Oct;10(4):240-6. doi: 10.1016/s1043-0679(98)70024-3.
Severe atherosclerosis of the ascending aorta is associated with an increased incidence of stroke after cardiac surgery. Direct intraoperative epiaortic scanning is a rapid and accurate means for detection of ascending aortic atherosclerosis. When severe atheromatous disease is detected, graft replacement of the ascending aorta is our preferred method of management. During an 11-year period, 81 patients (mean age 71 years) who underwent coronary artery bypass were found to have severe ascending aortic atherosclerosis by epiaortic scanning. Using hypothermic circulatory arrest, 80 patients underwent partial (5) or complete (75) ascending aortic replacement. One patient underwent resection of a protruding aortic atheroma. In addition to partial or total replacement of the ascending aorta, 34 patients had replacement of the aortic arch, 19 had a valve replacement, and 6 had carotid endarterectomy. The 30-day mortality was 8.6% (7 patients). Four patients (4.9%) sustained perioperative strokes and 2 (2.5%) sustained transient perioperative ischemic neurological deficits. The 3-year survival rate was 40%. There was one stroke 4 months postoperatively that eventually led to late death. Elective resection and graft replacement of the severely atherosclerotic ascending aorta using hypothermic circulatory arrest in patients undergoing cardiac operations is a safe procedure, associated with an acceptable incidence of postoperative stroke. The procedure may provide long-term protection from subsequent embolic cerebral vascular events. However, long-term survival has been disappointing and is primarily related to generalized atherosclerosis.
升主动脉严重动脉粥样硬化与心脏手术后中风发生率增加相关。术中直接进行主动脉外膜扫描是检测升主动脉动脉粥样硬化的一种快速且准确的方法。当检测到严重的动脉粥样硬化疾病时,升主动脉移植置换是我们首选的治疗方法。在11年期间,通过主动脉外膜扫描发现81例接受冠状动脉搭桥手术的患者(平均年龄71岁)存在严重的升主动脉动脉粥样硬化。采用低温循环停止技术,80例患者接受了部分(5例)或完全(75例)升主动脉置换。1例患者接受了突出的主动脉粥样瘤切除术。除了部分或全部置换升主动脉外,34例患者进行了主动脉弓置换,19例进行了瓣膜置换,6例进行了颈动脉内膜切除术。30天死亡率为8.6%(7例患者)。4例患者(4.9%)发生围手术期中风,2例(2.5%)出现围手术期短暂性缺血性神经功能缺损。3年生存率为40%。术后4个月发生1次中风,最终导致晚期死亡。对于接受心脏手术的患者,采用低温循环停止技术对严重动脉粥样硬化的升主动脉进行择期切除和移植置换是一种安全的手术,术后中风发生率可接受。该手术可能为后续的栓塞性脑血管事件提供长期保护。然而,长期生存率一直令人失望,主要与全身性动脉粥样硬化有关。