Rutala W A, Weber D J
University of North Carolina School of Medicine, the Department of Hospital Epidemiology, UNC Hospitals, Chapel Hill 27599-7030, USA.
Infect Control Hosp Epidemiol. 1998 Oct;19(10):798-804. doi: 10.1086/647730.
The elimination of chlorofluorocarbons by the Clean Air Act has led to the development of alternative technologies for low-temperature sterilization in the healthcare setting, including 100% ethylene oxide, ethylene oxide with other stabilizing gases, immersion in peracetic acid, and gas plasmas. The ideal sterilant does not exist, and infection control professionals should understand the advantages and disadvantages of these processes. However, when combined with adherence to standard cleaning protocols, the available data suggest that the currently available Food and Drug Administration-cleared low-temperature sterilization technologies can inactivate a clinically relevant inoculum of highly resistant organisms.
《清洁空气法》对氯氟烃的淘汰促使医疗保健领域开发了低温灭菌的替代技术，包括100%环氧乙烷、含其他稳定气体的环氧乙烷、浸泡在过氧乙酸中以及气体等离子体。理想的消毒剂并不存在，感染控制专业人员应了解这些方法的优缺点。然而，结合遵守标准清洁规程来看，现有数据表明，目前美国食品药品监督管理局批准的低温灭菌技术能够灭活临床上具有相关性的高抗性微生物接种体。
