Franco P, Szliwowski H, Dramaix M, Kahn A
Pediatric Sleep Unit, Erasmus Hospital, Brussels, Belgium.
Clin Auton Res. 1998 Oct;8(5):243-9. doi: 10.1007/BF02277969.
To determine the influence of sleep stages and night-time distribution on cardiac autonomic activity, the polysomnographic recordings of 18 victims of sudden infant death syndrome (SIDS) and of 36 control infants were studied. Autoregressive spectral analyses of heart rate (HR), using both short-term and whole-night methods, were evaluated as a function of sleep stages. The two main peaks of normalized LF and HF were computed during the night and the sympathovagal balance (LF/HF) was determined. In both NREM and REM sleep, SIDS infants were characterized by significantly lower normalized HF powers and higher LF/HF ratios. This finding was observed in both short-term and whole-night HR spectral analyses. In addition, SIDS victims were characterized by the presence of a high desynchronized peak of sympathetic tonus in the late hours of the night, a finding not seen in the control subjects. This report adds further indirect evidence for a possible sleep-related impairment of autonomic controls in some infants who died of SIDS.
为了确定睡眠阶段和夜间分布对心脏自主神经活动的影响，研究了18例婴儿猝死综合征（SIDS）受害者和36例对照婴儿的多导睡眠图记录。采用短期和整夜方法对心率（HR）进行自回归谱分析，并根据睡眠阶段进行评估。计算夜间归一化低频（LF）和高频（HF）的两个主要峰值，并确定交感迷走平衡（LF/HF）。在非快速眼动（NREM）睡眠和快速眼动（REM）睡眠中，SIDS婴儿的特征是归一化HF功率显著降低，LF/HF比值升高。这一发现在短期和整夜HR谱分析中均有观察到。此外，SIDS受害者的特征是在夜间较晚时出现交感神经张力高度去同步化峰值，这一发现在对照受试者中未见到。本报告为一些死于SIDS的婴儿可能存在与睡眠相关的自主神经控制受损提供了进一步的间接证据。
