Schechtman V L, Harper R K, Harper R M
Brain Research Institute, UCLA School of Medicine 90024-1761.
Electroencephalogr Clin Neurophysiol. 1995 Feb;94(2):95-102. doi: 10.1016/0013-4694(94)00263-k.
We assessed the patterning of slow-wave EEG activity during sleep in siblings of sudden infant death syndrome (SIDS) victims over the first 6 months of life. Twelve hour overnight physiologic recordings were obtained from 25 apparently healthy subsequent siblings of SIDS victims and 25 control infants at 1 week, and 1, 2, 3, 4 and 6 months of age. The EEG activity was electronically bandpass filtered, leaving primarily activity ranging from 0.5 to 2.5 Hz (the delta frequency), and the filtered traces were full-wave rectified and integrated over 1 min periods. The recordings were divided into four 3 h segments beginning at sleep onset, and the mean integrated delta activity during quiet sleep was determined for each segment of the night. At 3 and 4 months postnatal age, SIDS siblings displayed increased integrated delta amplitude in the early morning hours relative to control infants. Most SIDS deaths occur in the early morning hours during the 2-4 month age range. We thus speculate that increased delta activity may be indicative of increased arousal thresholds in the early morning, which may contribute to SIDS deaths.
我们评估了婴儿猝死综合征（SIDS）受害者的兄弟姐妹在生命最初6个月睡眠期间慢波脑电图活动的模式。对25名SIDS受害者的明显健康的同胞兄弟姐妹和25名对照婴儿在1周龄、1、2、3、4和6月龄时进行了12小时的夜间生理记录。脑电图活动经过电子带通滤波，主要保留0.5至2.5赫兹（δ频率）范围内的活动，滤波后的痕迹进行全波整流并在1分钟时间段内积分。记录从睡眠开始分为四个3小时段，确定夜间每个段安静睡眠期间的平均积分δ活动。在出生后3和4个月时，SIDS同胞兄弟姐妹相对于对照婴儿在清晨时段显示出积分δ振幅增加。大多数SIDS死亡发生在2至4个月龄范围内的清晨时段。因此，我们推测δ活动增加可能表明清晨唤醒阈值增加，这可能导致SIDS死亡。
