实验性活蜱传脑炎疫苗（Labgat E5 “14” 病毒克隆株）：单剂量免疫后1年和2年的志愿者。
Experimental live tick-borne encephalitis vaccine (Labgat E5 "14" virus clone): volunteers 1 and 2 years after single-dose immunization.
作者信息
Mayer V, Orolin D, Pogády J, Stárek M, Kubistová K, Gajdosová E, Buran I
出版信息
Acta Virol. 1976 Jun;20(3):215-25.
PMID:9802
Abstract
Groups of volunteers given intramuscularly 5 or 6.5 dex or perorally 6.5 dex newborn mouse icLD50 of the plaquesegregated "14" clone of the Langat E5 virus strain (tick-borne encephalitis comples) were followed for periods of 12 and 24-27 months. Circulating specific virus neutralizing antibodies persisted in them in the absence of apparent reaction as evidenced by clinical, electroencephalographic and cerebrospinal fluid findings.
摘要
给几组志愿者肌肉注射5或6.5个半数致死剂量（dex）的朗加特E5病毒株（蜱传脑炎复合体）“14”克隆的新生小鼠脑内半数致死剂量（icLD50），或口服6.5个dex，然后对他们进行12个月以及24至27个月的随访。临床、脑电图和脑脊液检查结果表明，在没有明显反应的情况下，他们体内持续存在循环特异性病毒中和抗体。
Zotero 插件