Aksel S, Wiebe R H, Tyson J E, Jones G S
Obstet Gynecol. 1976 Nov;48(5):598-602.
Menstrual bleeding with no detectable luteal function was observed cyclicly in 3 infertile patients. Anovulation was suspected and documented by basal body temperature charts and repeated endometrial biopsies prior to expected menses. A sporadic anovulatory cycle in a normally ovulating volunteer was studied and the hormonal parameters included for comparison. To elucidate the significance and the possible cause of this defect, five aluteal cycles were evaluated with serum follicle stimulating hormone (FSH), luteinizing hormone (LH), total estrogen, progestin, and prolactin determinations. No similar patterns of FSH, LH, or estrogen values were observed. No abnormality of prolactin levels was noted. The lack of progestin rise and proliferative endometrial biopsies during the second half of these cycles were the only consistent findings. When clomiphene citrate therapy was instituted, a luteal phase was promptly established.
在3例不孕患者中周期性观察到无明显黄体功能的月经出血。怀疑为无排卵，并通过基础体温图和预期月经前反复进行的子宫内膜活检予以证实。对一名正常排卵志愿者的偶发性无排卵周期进行了研究，并纳入激素参数进行比较。为阐明这一缺陷的意义及可能原因，对5个无黄体周期进行了血清促卵泡激素（FSH）、促黄体生成素（LH）、总雌激素、孕激素和催乳素测定评估。未观察到FSH、LH或雌激素值有类似模式。未发现催乳素水平异常。这些周期后半期孕激素未升高以及子宫内膜活检呈增殖期改变是仅有的一致发现。当给予枸橼酸氯米芬治疗时，黄体期迅速建立。
