Serrano-González C, Capablo J L, Cay E, Ara-Callizo J R, Velilla I, López-Gastón J I, Pérez López-Fraile I
Servicio de Neurología, Hospital Miguel Servet, Zaragoza, España.
Rev Neurol. 1998 Oct;27(158):658-62.
Aneurysms of the atrial septum (AAS) are uncommon. They have been considered to be related to embolic phenomena. They are usually associated with other cardiac anomalies, especially persistence of the formen ovale.
We studied six patients diagnosed during a period of 24 months as having ischemic ictus and AAS. They were investigated for vascular risk factors and possible causes of cardiac embolism by means of ECG, transthoracic and transoesophagic echography (ETE). Cases with the clinical characteristics of embolism were anticoagulated.
Five patients were men with an average age of 47.6 years. Three had the clinical features of established ictus, one of RIND and two of AIT. Three patients had vascular risk factors. The TSA study showed pathology of the carotid arteries to be present in three patients. In all six cases the AAS was identified on ETE. There were no thrombi in the atria in any case, and in two there was left-right communication. In four patients the condition was considered to have a cardio-embolic origin. No patient has had further episodes of cerebral ischaemia.
It seems there is a certain risk of cerebral embolus associated with AAS. The simultaneous presence of alterations in cardiac rhythm together with other structural cardiac pathology seems to have a synergic effect on this. Paradoxical embolism, arrhythmias and intra-aneurysmal thrombi appear to be the mechanisms involved in the appearance of emboli. The best therapeutic approach is still unknown. New studies are therefore necessary to establish whether or not it is necessary to anticoagulate these patients.
房间隔动脉瘤(AAS)并不常见。它们被认为与栓塞现象有关。通常与其他心脏异常相关,尤其是卵圆孔未闭。
我们研究了在24个月期间诊断为缺血性卒中合并AAS的6例患者。通过心电图、经胸和经食管超声心动图(ETE)对他们进行血管危险因素及心脏栓塞可能原因的调查。具有栓塞临床特征的病例进行抗凝治疗。
5例为男性,平均年龄47.6岁。3例有明确卒中的临床特征,1例为可逆性缺血性神经功能缺损,2例为急性缺血性卒中。3例患者有血管危险因素。经颅多普勒超声研究显示3例患者存在颈动脉病变。所有6例患者均经ETE确诊为AAS。所有病例心房均无血栓,2例存在左右分流。4例患者被认为病因是心源性栓塞。无患者再发脑缺血事件。
似乎AAS与脑栓塞存在一定风险。心律改变与其他心脏结构病变同时存在对此似乎有协同作用。反常栓塞、心律失常和动脉瘤内血栓似乎是栓子形成的机制。最佳治疗方法仍不明确。因此需要新的研究来确定是否有必要对这些患者进行抗凝治疗。