Kimber T E, Blumbergs P C, Rice J P, Hallpike J F, Edis R, Thompson P D, Suthers G
Department of Neurology, Royal Adelaide Hospital, South Australia, Australia.
J Neurol Sci. 1998 Sep 18;160(1):33-40. doi: 10.1016/s0022-510x(98)00169-5.
Female monozygotic twins developed upper and lower limb neurogenic weakness in their thirties, followed by cerebellar ataxia, dysarthria and death after an illness duration of about 20 years. Autopsy revealed pathological features typical of neuronal intranuclear inclusion disease (NIID) and positive ubiquitin immunostaining of the inclusions. Two adult sons of one of the twins have now developed an identical illness. This family provides strong evidence of an hereditary form of NIID.
