Mutation involving cytochrome P450IID6 in two Japanese patients with neuroleptic malignant syndrome.
作者信息
Kawanishi C, Shimoda Y, Fujimaki J, Onishi H, Suzuki K, Hanihara T, Sugiyama N, Kosaka K
机构信息
Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan.
出版信息
J Neurol Sci. 1998 Sep 18;160(1):102-4. doi: 10.1016/s0022-510x(98)00238-x.
PMID:9804127
Abstract
Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.
摘要
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