[暴露于己烯雌酚二丙酸酯的人淋巴细胞培养物中的染色体畸变和姐妹染色单体交换]
[Chromosome aberrations and sister chromatid exchanges in a human lymphocyte culture exposed to diethylstilbestrol dipropionate].
作者信息
Dzhangulashvili N A
出版信息
Tsitol Genet. 1982 Mar-Apr;16(2):24-9.
PMID:7101446
Abstract
Frequency of chromosome aberrations and sister chromatid exchanges (SCE) was studied in human lymphocyte culture treated with the synthetic nonsteroidal estrogen diethylstilbestrol-dipropionate in doses of 1.3 . 10(-7) M, 1.3 . 10(-6) M and 1.3 . 10(-5) M. Doses of 1.3 . 10(-6) M and 1.3 . 10(-5) M are shown to induce a significant increase in the chromosome aberration level mostly due to a rise in the number of polyploid cells. The same doses increase the frequency of SCE.
摘要
在人类淋巴细胞培养物中，研究了用剂量为1.3×10⁻⁷M、1.3×10⁻⁶M和1.3×10⁻⁵M的合成非甾体雌激素己烯雌酚二丙酸酯处理后的染色体畸变频率和姐妹染色单体交换（SCE）情况。结果显示，1.3×10⁻⁶M和1.3×10⁻⁵M的剂量大多由于多倍体细胞数量增加而导致染色体畸变水平显著升高。相同剂量也会增加SCE的频率。
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