Alquist M, Attman P O, Ipsen R, Jönsson L, Hegbrant J
Department of Nephrology, University Hospital of Lund, Sweden.
ASAIO J. 1998 Sep-Oct;44(5):M592-5. doi: 10.1097/00002480-199809000-00057.
Clinical investigation of a new concentrate system for preparing the acid concentrate in bicarbonate dialysis was performed to evaluate handling, safety aspects, and correct mixing of the final dialysis fluid. The system is characterized by an acid concentrate prepared from two components: a cartridge containing 1.1 kg dry sodium chloride and a concentrate bag with 500 ml of a highly concentrated solution of electrolytes (KCl, MgCl2, CaCl2) and acetic acid. The investigation comprised a total of 142 treatments. The concentrate system was well accepted by the clinical staff and considered safe and easy to handle. Marginal deviations in electrolyte concentration of the dialysis fluid relative to set values were observed, but were considered to lack biologic or clinical relevance. The new concentrate system will facilitate the handling of dialysis concentrates and provide a convenient means for individual tailoring of the dialysis fluid composition.
对一种用于碳酸氢盐透析中制备酸浓缩液的新型浓缩液系统进行了临床研究，以评估其操作便利性、安全性以及最终透析液的正确混合情况。该系统的特点是酸浓缩液由两种成分制备而成：一个装有1.1千克干燥氯化钠的药筒和一个装有500毫升高浓度电解质（氯化钾、氯化镁、氯化钙）和乙酸溶液的浓缩液袋。该研究共包括142次治疗。该浓缩液系统受到临床工作人员的广泛认可，被认为安全且易于操作。观察到透析液的电解质浓度相对于设定值存在轻微偏差，但认为这些偏差缺乏生物学或临床相关性。这种新型浓缩液系统将便于透析浓缩液的操作，并为个性化定制透析液成分提供一种便捷的方法。
