与小鼠胼胝体矢状面中部面积相关的数量性状基因座。

Quantitative trait loci implicated in corpus callosum midsagittal area in mice.

作者信息

Roy I L, Perez-Diaz F, Roubertoux P

机构信息

UPR CNRS 9074, Génétique, Neurogénétique, Comportement, Institut de Transgénose, CNRS, 3 B Rue de la Ferollerie, 45071, Orléans Cedex 02, France.

出版信息

Brain Res. 1998 Nov 16;811(1-2):173-6. doi: 10.1016/s0006-8993(98)00975-5.

DOI:10.1016/s0006-8993(98)00975-5

PMID:9804947

Abstract

The midsagittal area of the corpus callosum expressed as the percentage of the hemispheric surface is smaller in the NZB/BlNJ than in the C57BL/6By inbred strain of mice. We performed a QTL mapping analysis using 284 F2s. Two loci linked to this measure were found: the CCrSQTL1 and CCrSQTL2 at 87 and 67 centiMorgans from the centromere on chromosomes 1 and 4 respectively. The two loci interacted significantly. The total source of genetic variation contributed to 25% of the observed variance.

摘要

以半球表面百分比表示的胼胝体矢状中部区域，在新西兰黑/黑新西兰小鼠（NZB/BlNJ）中比在C57BL/6By近交系小鼠中更小。我们使用284只F2代小鼠进行了数量性状基因座（QTL）定位分析。发现了与该测量指标相关的两个基因座：分别位于1号和4号染色体着丝粒87和67厘摩处的CCrSQTL1和CCrSQTL2。这两个基因座存在显著相互作用。遗传变异的总来源占观察到的变异的25%。