Rosen G D, Sherman G F, Emsbo K, Mehler C, Galaburda A M
Dyslexia Neuroanatomical Research Laboratory, Beth Israel Hospital, Boston, Massachusetts.
Exp Neurol. 1990 Mar;107(3):271-6. doi: 10.1016/0014-4886(90)90145-i.
Differences in the midsagittal area of the corpus callosum have been reported between human males and females, between handled and nonhandled rats, and both within and between various strains of mice. This measure has, in addition, been related to handedness in humans and "pawedness" in certain strains of mice. The present study investigated the between- and within-strain differences in three inbred strains of mice, two with autoimmune disorders and spontaneously occurring developmental neuropathology, in the midsagittal area of the corpus callosum, the total neocortical volume, and the asymmetry of the neocortex. These morphometric measures were obtained from coronally sectioned celloidin-embedded material from New Zealand Black (NZB/BINJ), BXSB/MpJ, and DBA/2J mouse strains. NZB mice had a total neocortical volume larger than that of either the BXSB or DBA strains, whereas the BSXB mice had a midsagittal area of the corpus callosum larger than that of either of the other two strains. In addition, there was a positive correlation between these two measures. There was no correlation between total neocortical asymmetry and midsagittal area of the corpus callosum in any of the three strains. Finally, there were no differences in any morphometric measure between animals with or without developmental neuropathology in any given strain.
据报道，人类男性和女性之间、经过处理和未经处理的大鼠之间以及不同品系小鼠内部和不同品系小鼠之间，胼胝体矢状中部区域存在差异。此外，这一指标还与人类的利手性以及某些品系小鼠的“爪偏好性”有关。本研究调查了三种近交系小鼠品系内部和品系之间在胼胝体矢状中部区域、新皮质总体积以及新皮质不对称性方面的差异，其中两种品系患有自身免疫性疾病且存在自发的发育性神经病理学变化。这些形态测量指标是从新西兰黑（NZB/BINJ）、BXSB/MpJ和DBA/2J小鼠品系的冠状切片赛璐珞包埋材料中获取的。NZB小鼠的新皮质总体积大于BXSB或DBA品系，而BXSB小鼠的胼胝体矢状中部区域大于其他两个品系中的任何一个。此外，这两个指标之间存在正相关。在这三个品系中的任何一个品系中，新皮质总不对称性与胼胝体矢状中部区域之间均无相关性。最后，在任何给定品系中，有或没有发育性神经病理学变化的动物在任何形态测量指标上均无差异。
