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氨氯地平敏感钠通道在仓鼠口腔中的分布。

Distribution of amiloride-sensitive sodium channels in the oral cavity of the hamster.

作者信息

Gilbertson T A, Fontenot D T

机构信息

Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808-4124, USA.

出版信息

Chem Senses. 1998 Oct;23(5):495-9. doi: 10.1093/chemse/23.5.495.

DOI:10.1093/chemse/23.5.495
PMID:9805633
Abstract

The distribution of amiloride-sensitive sodium channels (ASSCs) in taste buds isolated from the oral cavity of hamsters was assessed by patch clamp recording. In contrast to the case for rats, taste cells from the fungiform, foliate and vallate papillae and from the soft palate all contain functional ASSCs. The differential distribution of ASSCs between the hamster and the rat may be important for understanding the physiology underlying the differing behavioral responses of these species to sodium salts.

摘要

通过膜片钳记录评估了从仓鼠口腔分离的味蕾中氨氯地平敏感钠通道(ASSCs)的分布。与大鼠的情况不同,来自菌状乳头、叶状乳头和轮廓乳头以及软腭的味觉细胞均含有功能性ASSCs。仓鼠和大鼠之间ASSCs的差异分布可能对于理解这些物种对钠盐不同行为反应背后的生理学机制很重要。

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引用本文的文献

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Is the Amiloride-Sensitive Na+ Channel in Taste Cells Really ENaC?味蕾细胞中的阿米洛利敏感钠离子通道真的是 ENaC 吗?
Chem Senses. 2020 May 21;45(4):233-234. doi: 10.1093/chemse/bjaa011.
2
Insulin activates epithelial sodium channel (ENaC) via phosphoinositide 3-kinase in mammalian taste receptor cells.胰岛素通过磷酸肌醇 3-激酶激活哺乳动物味觉感受器细胞中的上皮钠通道 (ENaC)。
Am J Physiol Cell Physiol. 2011 Apr;300(4):C860-71. doi: 10.1152/ajpcell.00318.2010. Epub 2010 Nov 24.
3
Amiloride-sensitive channels in type I fungiform taste cells in mouse.
小鼠I型菌状味觉细胞中的阿米洛利敏感通道。
BMC Neurosci. 2008 Jan 2;9:1. doi: 10.1186/1471-2202-9-1.