通过电子显微镜研究强毒株和减毒株伪狂犬病病毒对海拉细胞的感染。
Infection of Hela cells with a virulent and an attenuated strain of pseudorabies virus studied by electron microscopy.
作者信息
Golais F, Ciampor F
出版信息
Acta Virol. 1976 Jun;20(3):247-9.
PMID:9806
Abstract
Hollow-core particles, forming crystals in nuclei, prevailed in HeLa cells infected with an attenuated strain of pseudorabies virus (PRV). After infection with a virulent PRV strain, the cells contained mainly fully infectious dense-core particles. These findings might explain the lower susceptibility of HeLa and some other human cells to infection with attenuated strains of PRV as compared to virulent strains.
摘要
在感染了伪狂犬病病毒（PRV）减毒株的HeLa细胞中，以在细胞核中形成晶体的空心颗粒为主。在用强毒PRV毒株感染后，细胞中主要含有完全具有感染性的致密颗粒。这些发现可能解释了与强毒株相比，HeLa细胞和其他一些人类细胞对PRV减毒株感染的易感性较低的原因。
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