Frei M R, Jauchem J R, Dusch S J, Merritt J H, Berger R E, Stedham M A
Department of Biology, Trinity University, San Antonio, Texas 78284, USA.
Radiat Res. 1998 Nov;150(5):568-76.
In a previous study (Frei et al., Bioelectromagnetics 19, 20-31, 1998), we showed that low-level (0.3 W/kg), long-term exposure of mice prone to mammary tumors to 2450 MHz radiofrequency (RF) radiation did not affect the incidence of mammary tumors, latency to tumor onset, tumor growth rate or animal survival when compared to sham-irradiated animals. In the current study, the specific absorption rate (SAR) was increased from 0.3 W/kg to 1.0 W/kg. The same biological end points were used. One hundred C3H/HeJ mice were exposed in circularly polarized waveguides for 78 weeks (20 h/day, 7 days/week) to continuous-wave, 2450 MHz RF radiation; 100 mice were sham-exposed. There was no significant difference between exposed and sham-exposed groups with respect to the incidence of palpated mammary tumors (sham-exposed = 30%; irradiated = 38%), latency to tumor onset (sham-exposed = 62.0 +/- 2.3 weeks; irradiated = 62.5 +/- 2.2 weeks) and rate of tumor growth. Histopathological evaluations revealed no significant difference in numbers of malignant, metastatic or benign neoplasms between the two groups. Thus long-term exposures of mice prone to mammary tumors to 2450 MHz RF radiation at SARs of 0.3 and 1.0 W/kg had no significant effects when compared to sham-irradiated animals.
在之前的一项研究中（Frei等人，《生物电磁学》19卷，20 - 31页，1998年），我们发现，与假照射动物相比，易患乳腺肿瘤的小鼠长期暴露于2450 MHz射频（RF）辐射下，低水平（0.3 W/kg）并不会影响乳腺肿瘤的发病率、肿瘤发生潜伏期、肿瘤生长速率或动物存活率。在当前研究中，比吸收率（SAR）从0.3 W/kg提高到了1.0 W/kg。使用了相同的生物学终点指标。将100只C3H/HeJ小鼠置于圆极化波导中，连续78周（每天20小时，每周7天）暴露于2450 MHz连续波RF辐射；100只小鼠进行假暴露。在可触及乳腺肿瘤的发病率（假暴露 = 30%；照射 = 38%）、肿瘤发生潜伏期（假暴露 = 62.0 ± 2.3周；照射 = 62.5 ± 2.2周）和肿瘤生长速率方面，暴露组和假暴露组之间没有显著差异。组织病理学评估显示，两组之间恶性、转移性或良性肿瘤的数量没有显著差异。因此，与假照射动物相比，易患乳腺肿瘤的小鼠长期暴露于比吸收率为0.3和1.0 W/kg的2450 MHz RF辐射下没有显著影响。
