Oberto Germano, Rolfo Katia, Yu Ping, Carbonatto Michela, Peano Sergio, Kuster Niels, Ebert Sven, Tofani Santi
Istituto di Ricerche Biomediche LCG-RBM, 10010 Colleretto Giacosa (Torino) Italy.
Radiat Res. 2007 Sep;168(3):316-26. doi: 10.1667/rr0425.1.
In an 18-month carcinogenicity study, Pim1 transgenic mice were exposed to pulsed 900 MHz (pulse width: 0.577 ms; pulse repetition rate: 217 Hz) radiofrequency (RF) radiation at a whole-body specific absorption rate (SAR) of 0.5, 1.4 or 4.0 W/kg [uncertainty (k = 2): 2.6 dB; lifetime variation (k = 1): 1.2 dB]. A total of 500 mice, 50 per sex per group, were exposed, sham-exposed or used as cage controls. The experiment was an extension of a previously published study in female Pim1 transgenic mice conducted by Repacholi et al. (Radiat. Res. 147, 631-640, 1997) that reported a significant increase in lymphomas after exposure to the same 900 MHz RF signal. Animals were exposed for 1 h/day, 7 days/week in plastic tubes similar to those used in inhalation studies to obtain well-defined uniform exposure. The study was conducted blind. The highest exposure level (4 W/kg) used in this study resulted in organ-averaged SARs that are above the peak spatial SAR limits allowed by the ICNIRP (International Commission on Non-ionizing Radiation Protection) standard for environmental exposures. The whole-body average was about three times greater than the highest average SAR reported in the earlier study by Repacholi et al. The results of this study do not suggest any effect of 217 Hz-pulsed RF-radiation exposure (pulse width: 0.577 ms) on the incidence of tumors at any site, and thus the findings of Repacholi et al. were not confirmed. Overall, the study shows no effect of RF radiation under the conditions used on the incidence of any neoplastic or non-neoplastic lesion, and thus the study does not provide evidence that RF radiation possesses carcinogenic potential.
在一项为期18个月的致癌性研究中，Pim1转基因小鼠暴露于脉冲频率为900 MHz（脉冲宽度：0.577毫秒；脉冲重复率：217赫兹）的射频（RF）辐射下，全身比吸收率（SAR）分别为0.5、1.4或4.0瓦/千克[不确定度（k = 2）：2.6分贝；寿命期变化（k = 1）：1.2分贝]。总共500只小鼠，每组雌雄各50只，分别接受辐射暴露、假暴露或作为笼养对照。该实验是Repacholi等人（《辐射研究》147卷，631 - 640页，1997年）之前发表的一项针对雌性Pim1转基因小鼠研究的扩展，该研究报告称暴露于相同的900 MHz射频信号后淋巴瘤显著增加。动物每天暴露1小时，每周7天，置于类似于吸入研究中使用的塑料管中，以获得明确的均匀暴露。该研究采用盲法进行。本研究中使用的最高暴露水平（4瓦/千克）导致器官平均比吸收率高于国际非电离辐射防护委员会（ICNIRP）环境暴露标准允许的峰值空间比吸收率限值。全身平均值比Repacholi等人早期研究中报告的最高平均比吸收率大约高三倍。本研究结果未表明217赫兹脉冲射频辐射暴露（脉冲宽度：0.577毫秒）对任何部位肿瘤发生率有任何影响，因此未证实Repacholi等人的研究结果。总体而言，该研究表明在所使用的条件下射频辐射对任何肿瘤性或非肿瘤性病变的发生率均无影响，因此该研究未提供证据表明射频辐射具有致癌潜力。
